Outlook 2013 2016

File > [Info]

[Account and Social Network Settings]
[Account Settings…]

[Change…]

Change E-mail Account
Outgoing mail server (SMTP): rsxxx.realsender.com
[More Settings…]

Outgoing Server
[x] My outgoing server (SMTP) requires authentication
[x] Log on using
User Name: (the one we sent you)
Password: (the one we sent you)[x] Remember password
[OK]

Advanced
Use the following type of encrypted connection: TLS
[OK]